An artificial neural network (AI) designed by an international team involving UCL can translate raw data from brain activity, paving the way for new discoveries and a closer integration between technology and the brain.
The study published today in eLife, co-led by the Kavli Institute for Systems Neuroscience in Trondheim and the Max Planck Institute for Human Cognitive and Brain Sciences Leipzig and funded by Wellcome and the European Research Council, shows that a convolutional neural network, a specific type of deep learning algorithm, is able to decode many different behaviors and stimuli from a wide variety of brain regions in different species, including humans.
Lead researcher Markus Frey (Kavli Institute for Systems Neuroscience), said, “Neuroscientists have been able to record larger and larger datasets from the brain but understanding the information contained in that data—reading the neural code—is still a hard problem. In most cases we don’t know what messages are being transmitted.
“We wanted to develop an automatic method to analyze raw neural data of many different types, circumventing the need to manually decipher them.”
They tested the network, called DeepInsight, on neural signals from rats exploring an open arena and found it was able to precisely predict the position, head direction, and running speed of the animals. Even without manual processing, the results were more accurate than those obtained with conventional analyses.
Senior author Professor Caswell Barry (UCL Cell & Developmental Biology), said, “Existing methods miss a lot of potential information in neural recordings because we can only decode the elements that we already understand. Our network is able to access much more of the neural code and in doing so teaches us to read some of those other elements.
“We are able to decode neural data more accurately than before, but the real advance is that the network is not constrained by existing knowledge.”
The team found that their model was able to identify new aspects of the neural code, which they show by detecting a previously unrecognized representation of head direction, encoded by interneurons in a region of the hippocampus that is among the first to show functional defects in people with Alzheimer’s disease.
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