If you’ve been worried by recent news stories about a strain of covid called “delta plus,” it may freak you out to hear that scientists just expanded the delta family from four variants to 13.
Please take a deep breath. Scientists would really like you to understand that there’s no evidence delta has learned any new tricks, and these new names are for helping keep track of covid’s evolution—not nine new reasons to panic. And many researchers are also really, really hoping you’ll stop saying “delta plus.”
“The name ‘delta plus’ is completely incorrect, because it gives the perception that this will cause more damage,” says Anderson Brito, a member of the Pango Lineage Designation Committee, which assigns scientific names like B.1.1.7 to new branches of the virus. “So far, we have no evidence any of the mutations affect behavior compared to the original delta variant.”
It might be helpful to think of covid as a tree. Delta is like a thick branch on that tree—a big family of viruses that share a common ancestor and some of the same mutations, which let them spread between people more quickly. When the big branch grows new twigs, which happens all the time, scientists keep track by using technical names that include numbers and letters. But a new scientific name doesn’t mean those viruses will act any differently from the branch they grew from—and if one of those new branches does start to change its behavior, it gets a new Greek letter, not a “plus.”
(Now is a good time to note that while some of delta’s mutations make it more transmissible, vaccines are still very good at preventing severe illness from every known strain of covid.)
What’s in a name?
This naming confusion stems mostly from the way journalists (and their scientist sources) have blended two commonly used systems of tracking covid’s evolution—despite the fact that the approaches have very different strategies and goals.
The alphanumeric system that gave the first delta variant its scientific name—B.1.617.2—is called Pango. It’s meant for researchers tracking small genetic changes to the virus. It doesn’t determine whether new lineages act differently in people, just whether they’re different on a molecular level. There are currently over 1,300 Pango lineages, 13 of which are considered part of the delta family.
The name delta, meanwhile, comes from the WHO system, which is meant to simplify genomics for the general public. It gives names to related covid samples if it believes they may be of particular interest. There are currently eight families with Greek letters, but until there’s evidence a new sublineage of the first delta strain is acting differently from its parents, the WHO considers them all to be delta.
“Delta plus” takes the WHO designation and mixes it up with Pango’s lineage information. It doesn’t mean the virus is more dangerous or more concerning.
“People get quite anxious when they see a new Pango name. But we should not be upset by the discovery of new variants. All the time, we see new variants popping up with no different behavior at all,” says Brito. “If we have evidence a new lineage is more threatening, WHO will give it a new name.”
“For a genomic scientist like me, I want to know what variations we’re seeing,” says Kelsey Florek, senior genomics and data scientist for the Wisconsin state public health lab. “For the greater public, it doesn’t really make a difference. Classifying them all as delta is sufficient for communicating with policy makers, public health, and the public.”
Fundamentally, viral evolution works like any other kind. As the virus spreads through the body, it makes copies of itself, which often have small mistakes and changes. Most of these are dead ends, but occasionally, a copy with a mistake replicates enough inside a person to spread to someone else.
As the virus spreads from person to person, it accumulates those small changes, allowing scientists to follow patterns of transmission—the same way we can look at human genomes and identify which people are related. But in a virus, most of those genetic changes have no impact on the way it actually affects individuals and communities.
Genomic scientists still need a way to track that viral evolution, though, both for basic science and to identify any changes in behavior as early as possible. That’s why they are keeping a close eye on patterns in delta, especially, since it’s spreading so rapidly. The Pango team continues to split descendants of the first delta lineage, B.1.617.2, into subcategories of related cases.
Until recently, it had registered 617.2 itself plus three “children,” called AY.1, AY.2, and AY.3. This week, the team decided to split those children into 12 families in order to better track small-scale local changes—hence the total of 13 delta variants. None of this means the virus itself has suddenly changed.
“Especially at the margins, with these emerging variants, you are splitting hairs,” says Duncan MacCannell, chief scientific officer of the CDC’s Office of Advanced Molecular Detection. “Depending on how those definitions are crafted and refined, the hairs can split in different ways.”
A paper recently published in the journal ACS Applied Energy Materials demonstrated the feasibility of using a covalent organic framework (COF)-based nanofluidic hybrid membranes (NHMs) to attain enhanced interfacial ion transport for the generation of osmotic [...]
The excess fluoroquinolones (FQs) discharged into the aquatic environment due to human activities must be removed cost-effectively. In an article published in the Journal of Cleaner Production, the authors fabricated an environment-friendly dealkaline lignin-grafted Fe3O4 nanoparticles [...]
Controlling strong electromagnetic fields on nanoparticles is the key to triggering targeted molecular reactions on their surfaces. Such control over strong fields is achieved via laser light. Although laser-induced formation and breaking of molecular [...]
A paper recently published in the journal Nature Communications demonstrated an effective method to realize on-chip nanophotonic topological rainbow devices using the concept of synthetic dimensions. Importance of Synthetic Dimensions for the Construction of Topological Nanophotonics [...]
In a study available in the journal Materials Today: Proceedings, silver nanoparticles (Ag NPs) were fabricated using a green method using Citrus X sinensis. Methylthioninium Chloride (MB) Dyes Threatening the Environment Dye and sewage drainage into [...]
Public health experts are divided over how many people are getting long COVID-19, a potentially debilitating condition that comes after a patient has recovered from the coronavirus. Ill effects from the condition can include [...]
Well over two years into the pandemic, hundreds of thousands of COVID cases continue to be recorded around the world every day. With the rise of new variants, the symptoms of COVID have also evolved. Initially, [...]
Drug resistance is a common phenomenon, with drugs becoming less and less effective as their usage increases. To address this issue, a novel technique employing conjugated polymer-based nanoparticles is presented in the study published [...]
Microrobots have the potential to revolutionize medicine. Researchers at the Max Planck ETH Centre for Learning Systems have now developed an imaging technique that for the first time recognises cell-sized microrobots individually and at [...]
Scientists have recently developed multifunctional hexagonal NaxWO3 nanocrystals that can serve as microwave sensitizers to kill cancer cells as well as improve the overall chemodynamic therapy (CDT). This study is available as a pre-proof in Chemical Engineering Journal. [...]
Apple’s visionary founder, the late Steve Jobs once said, “the biggest innovations of the 21st century will be at the intersection of biology and technology”. And that prediction is coming true in the drug [...]
Chemical separation processes are essential in the manufacturing of many products from gasoline to whiskey. Such processes are energetically costly, accounting for approximately 10–15 percent of global energy consumption. In particular, the use of [...]
Scientists have recently developed electrochemical immunosensors based on graphene oxide−gold (GO−Au) nanocomposites. These immunosensors are highly sensitive with dual function, i.e., they can detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen and antibody. [...]
Omicron relatives called BA.4 and BA.5 are behind a fresh wave of COVID-19 in South Africa, and could be signs of a more predictable future for SARS-CoV-2. Here we go again. Nearly six months [...]