A new COVID variant has recently been detected in several countries including the UK, US, India, Australia and Germany.
Called BA.2.75, it’s a subvariant of omicron. You might have also heard it called “Centaurus”, the name of a constellation and given to BA.2.75 by a Twitter user.
The World Health Organization has classified BA.2.75 as a variant of interest, rather than a variant of concern. This means it’s being monitored but there’s not yet evidence it will cause problems.
The numbers of BA.2.75 infections are still relatively low. Most infections in the UK remain driven by the omicron subvariants BA.4 and BA.5. BA.5 in particular is similarly dominant in other countries where BA.2.75 has been detected.
However, BA.2.75 is becoming more common in India (where it was first detected, back in May), suggesting it has advantages relative to current circulating variants. Some have noted that BA.2.75 is spreading in regions of India where it doesn’t have to compete with BA.5, but rather with the variant it evolved from, BA.2.
That said, some data from India indicates that BA.2.75 may have already peaked. And importantly, there hasn’t been a big increase in hospitalisations or deaths in India from BA.2.75.
Given this, BA.2.75 has quickly gained an additional nickname: a “scariant”.
Why are we still seeing new variants?
As most of the global population has now either been vaccinated, infected, or both, variants which can infect people despite their immunity will have an advantage. So SARS-CoV-2 (the virus that causes COVID) is constantly evolving to gain this advantage.
New variants which have mutations that evade our immunity will replicate and spread, leading to waves of infections. We’ve seen this most recently with BA.4 and BA.5.
The memory immune system recognises infections based on molecular structures of viruses and other pathogens. Mutations change the molecular structure of each SARS-CoV-2 variant slightly, making it more difficult for our immune system to recognise and respond to the virus. This is often called “immune evasion”.
Read more: SARS-CoV-2 mutations: why the virus might still have some tricks to pull
The concern around BA.2.75 is that is has picked up a number of mutations, which might indicate that this variant can evade immunity. But there’s no good evidence at this stage that BA.2.75 can evade the immune system in a significant way.
Most of BA.2.75 is structurally the same as omicron and the original Wuhan variant. Although BA.2.75 has picked up a few mutations, it isn’t fundamentally a different virus.
The memory immune system will still act against BA.2.75, which is what we’ve seen with omicron. This immunity might not be enough to stop reinfection, but should reduce the severity of a BA.2.75 infection.
While there are concerns BA.2.75 could spread more quickly than other variants, we don’t have any clear evidence on this yet. It seems to have shown an increase which has levelled off or even dropped relative to a few weeks ago. If this is the case there’s a chance it might even fizzle out in another few weeks.
But, if BA.2.75 does have some immune evasion properties, it could cause another wave through the UK and elsewhere. Still, this would likely spike and then fizzle out like alpha, delta and omicron BA.1.
Improving vaccines could be our best shot
Thanks to vaccination, if we did face a BA.2.75 wave, we wouldn’t expect the level of deaths and hospitalisations seen earlier in the pandemic. But we know large numbers of cases can still cause significant disruption. And importantly, the constant wave of new variants is still a deadly threat to people who are vulnerable. So how do we overcome this?
One solution could be universal COVID vaccines, which would work against any COVID variants. The aim of a universal vaccine is to induce immunity against a very wide range of molecular structures. It’s akin to fishing with a wider net, making it harder for the fish to swim out of the way.
A pan-coronavirus vaccine is a similar concept but would likely try to induce immunity against the molecular structures common to all coronaviruses. As well providing immunity against new SARS-CoV-2 variants, a pan-coronavirus vaccine might also confer immunity against the next coronavirus pandemic. Some of these vaccines look set to move into clinical trials in the next few years.
A second solution may be to produce vaccines which induce better immunity in the respiratory system. These largely involve vaccines given through your nose, training the immune system to make more antibodies in the mucus of the nose and throat.
This type of immunity might help stop SARS-CoV-2 infecting and replicating at the point of entry into our cells, which could slow down the rate at which new variants have the opportunity to emerge. At least 12 of these intranasal vaccines are in clinical trials.
Read more: Coronavirus: once you have antibodies, are you safe?
Right now, I would put my money on BA.2.75 fizzling out without a major wave of infections. But the next omicron subvariant, and the next pandemic, will inevitably come. New vaccine approaches might make us better prepared.

News
AI matches doctors in mapping lung tumors for radiation therapy
In radiation therapy, precision can save lives. Oncologists must carefully map the size and location of a tumor before delivering high-dose radiation to destroy cancer cells while sparing healthy tissue. But this process, called [...]
Scientists Finally “See” Key Protein That Controls Inflammation
Researchers used advanced microscopy to uncover important protein structures. For the first time, two important protein structures in the human body are being visualized, thanks in part to cutting-edge technology at the University of [...]
AI tool detects 9 types of dementia from a single brain scan
Mayo Clinic researchers have developed a new artificial intelligence (AI) tool that helps clinicians identify brain activity patterns linked to nine types of dementia, including Alzheimer's disease, using a single, widely available scan—a transformative [...]
Is plastic packaging putting more than just food on your plate?
New research reveals that common food packaging and utensils can shed microscopic plastics into our food, prompting urgent calls for stricter testing and updated regulations to protect public health. Beyond microplastics: The analysis intentionally [...]
Aging Spreads Through the Bloodstream
Summary: New research reveals that aging isn’t just a local cellular process—it can spread throughout the body via the bloodstream. A redox-sensitive protein called ReHMGB1, secreted by senescent cells, was found to trigger aging features [...]
AI and nanomedicine find rare biomarkers for prostrate cancer and atherosclerosis
Imagine a stadium packed with 75,000 fans, all wearing green and white jerseys—except one person in a solid green shirt. Finding that person would be tough. That's how hard it is for scientists to [...]
Are Pesticides Breeding the Next Pandemic? Experts Warn of Fungal Superbugs
Fungicides used in agriculture have been linked to an increase in resistance to antifungal drugs in both humans and animals. Fungal infections are on the rise, and two UC Davis infectious disease experts, Dr. George Thompson [...]
Scientists Crack the 500-Million-Year-Old Code That Controls Your Immune System
A collaborative team from Penn Medicine and Penn Engineering has uncovered the mathematical principles behind a 500-million-year-old protein network that determines whether foreign materials are recognized as friend or foe. How does your body [...]
Team discovers how tiny parts of cells stay organized, new insights for blocking cancer growth
A team of international researchers led by scientists at City of Hope provides the most thorough account yet of an elusive target for cancer treatment. Published in Science Advances, the study suggests a complex signaling [...]
Nanomaterials in Ophthalmology: A Review
Eye diseases are becoming more common. In 2020, over 250 million people had mild vision problems, and 295 million experienced moderate to severe ocular conditions. In response, researchers are turning to nanotechnology and nanomaterials—tools that are transforming [...]
Natural Plant Extract Removes up to 90% of Microplastics From Water
Researchers found that natural polymers derived from okra and fenugreek are highly effective at removing microplastics from water. The same sticky substances that make okra slimy and give fenugreek its gel-like texture could help [...]
Instant coffee may damage your eyes, genetic study finds
A new genetic study shows that just one extra cup of instant coffee a day could significantly increase your risk of developing dry AMD, shedding fresh light on how our daily beverage choices may [...]
Nanoneedle patch offers painless alternative to traditional cancer biopsies
A patch containing tens of millions of microscopic nanoneedles could soon replace traditional biopsies, scientists have found. The patch offers a painless and less invasive alternative for millions of patients worldwide who undergo biopsies [...]
Small antibodies provide broad protection against SARS coronaviruses
Scientists have discovered a unique class of small antibodies that are strongly protective against a wide range of SARS coronaviruses, including SARS-CoV-1 and numerous early and recent SARS-CoV-2 variants. The unique antibodies target an [...]
Controlling This One Molecule Could Halt Alzheimer’s in Its Tracks
New research identifies the immune molecule STING as a driver of brain damage in Alzheimer’s. A new approach to Alzheimer’s disease has led to an exciting discovery that could help stop the devastating cognitive decline [...]
Cyborg tadpoles are helping us learn how brain development starts
How does our brain, which is capable of generating complex thoughts, actions and even self-reflection, grow out of essentially nothing? An experiment in tadpoles, in which an electronic implant was incorporated into a precursor [...]