Brain-computer interfaces, or BCIs, hold immense potential for individuals with a wide range of neurological conditions, but the road to implementation is long and nuanced for both the invasive and noninvasive versions of the technology. Bin He of Carnegie Mellon University is highly driven to improve noninvasive BCIs, and his lab uses an innovative [...]
Groundbreaking maps reveal the complex gene regulation in brains with and without mental disorders, enhancing the understanding of mental illnesses and potential treatments. A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the [...]
Researchers have discovered sex-specific differences in the nerve cells that generate pain, paving the way for personalized pain management treatments based on patient sex. Research indicates that men and women experience pain differently, but the reasons behind this have remained unclear. A new study from the University of Arizona Health Sciences, published in the journal BRAIN, [...]
Researchers at the University of California San Diego discovered that an unusually large brain could be the first sign of autism, potentially detectable in as early as the first trimester. Some children with autism face severe, enduring challenges including developmental delays, social difficulties, and possibly an inability to speak. Meanwhile, others may have milder [...]
Clinical-stage biotech Alzheon has completed a $100 million Series E financing round to advance the development and commercialization of its oral drug for Alzheimer’s disease. The drug, called ALZ-801 (valiltramiprosate), is designed to inhibit the formation of soluble toxic beta amyloid oligomers, which are implicated in the cognitive decline observed in Alzheimer’s patients. The small molecule [...]
Two human cases of "dual mutant" strains of H1N1 flu have been reported by U.S. health officials. Unfortunately, the genetic changes appear to render the leading flu antiviral, Tamiflu, less effective, researchers from the U.S. Centers for Disease Control and Prevention noted. The new analysis, published Wednesday in the agency's Emerging Infectious Diseases journal, describes these two concerning [...]
Researchers have discovered the reason why targeted treatment for non-small cell lung cancer fails to work for some patients, particularly those who have never smoked. The study shows that lung cancer cells with two particular genetic mutations are more likely to double their genome, which helps them to withstand treatment and develop resistance to [...]
In a recent study published in Cancer Discovery, researchers developed and validated a blood-based, cell-free deoxyribonucleic acid (cfDNA) fragmentome assay for lung cancer detection, which, if the results were positive, would be followed by low-dose computed tomography (LDCT). Introduction Lung cancer is a major death cause, and yearly screening is crucial. However, chest LDCT has [...]
Research from Weill Cornell Medicine reveals that astrocyte receptors impact cognitive functions differently in males and females, suggesting a need for sex-specific approaches in developing treatments targeting these brain cells. Scientists at Weill Cornell Medicine have discovered the first evidence that receptors in astrocytes, brain cells that support and regulate neurons, can have contrasting effects on [...]
Columbia University’s research has uncovered a longstanding error in identifying gut stem cells, finding the true stem cells in a different site, which could revolutionize regenerative medicine by applying these findings to other organs. Two independent studies by Columbia scientists suggest that research into the gut’s stem cells over the past 15 years has been marred [...]
