Researchers have developed an artificial intelligence model, TIGER, that predicts the on- and off-target activity of RNA-targeting CRISPR tools. This innovation, detailed in a study published in Nature Biotechnology, can accurately design guide RNAs, modulate gene expression, and is poised to drive advancements in CRISPR-based therapies. Artificial intelligence can predict on- and off-target activity of [...]
Scientists have illuminated the process by which a highly infectious virus, recently transmitted from animals to humans, gains entry into human cells. Dr. Ariel Isaacs and Dr. Yu Shang Low, from The University of Queensland, have successfully revealed the structure of the fusion protein of the Langya virus. This virus was first identified in humans [...]
Alzheimer’s disease, an irreversible form of dementia, is considered the world’s most common neurodegenerative disease. The prime risk factor for Alzheimer’s is age, although it remains unclear why. It is known that the insulating layer around nerve cells in the brain, named myelin, degenerates with age. Researchers at the Max Planck Institute (MPI) for Multidisciplinary Sciences [...]
A study of more than 22,000 people with multiple sclerosis (MS) has for the first time identified a genetic variant associated with faster progression of the disease, an accumulation of disability that can rob patients of their mobility and independence over time. Multiple sclerosis begins as an autoimmune disease where the immune system attacks [...]
Incorporating a personalized mRNA vaccine, designed to match an individual’s tumor genetics, into standard immunotherapy substantially boosts survival rates and reduces the recurrence of high-risk skin cancers in patients who have had these malignancies removed. Global trials that could revolutionize cancer treatment and save countless lives are being led by scientists from Edith Cowan University [...]
What determines whether an individual will develop Alzheimer’s disease, and why do many with the disease’s characteristic toxic amyloid accumulations in the brain never exhibit associated dementia symptoms? These perplexing questions have long puzzled researchers. Scientists from the University of Pittsburgh School of Medicine seem to have unveiled the answer. According to their groundbreaking research published in Nature Medicine, [...]
A study, involving the London School of Hygiene & Tropical Medicine (LSHTM) researchers, has shown that tranexamic acid (TXA), a drug aimed at tackling serious postpartum bleeding, can be safely administered intramuscularly to pregnant women, quickly achieving effective therapeutic levels. These results, derived from the Woman-PharmacoTXA Phase 2 trial, underscore the potential of using intramuscular injection [...]
Researchers from The University of Queensland have made a dust from baker's yeast that can detect COVID-19 and could safeguard communities against future pandemics. The powdery "nanoprobes" developed at UQ's Australian Institute for Bioengineering and Nanotechnology (AIBN) are synthetic yeast fragments which can be deployed in environments such as airports, hospitals, stadiums and sewers [...]
A new research has revealed a possible connection between human brain and cosmos on a quantum scale. Introduction: Connection between human brain and cosmos The human brain, with its intricate networks of neurons, has long been a subject of fascination and mystery. Concurrently, the cosmos, with its vastness and complexity, has intrigued scientists and [...]
When we breathe, the SARS-CoV-2 virus enters the body through the cells of the upper respiratory tract. Sensing an invader, the epithelial cells, which are the first line of defense, mount an immediate and broad "innate" defense and trigger an alarm. The immune system then launches a cascade of vigorous, targeted attacks. Understanding how these [...]
