The blood-brain barrier blocks the entry of antibodies into the brain. This limits the potential use of antibody therapeutics to treat brain diseases, such as brain tumors. Elsewhere in the body, more than 100 United States Food and Drug Administration-approved therapeutic antibodies are used by medical teams to treat cancers and autoimmune, infectious and [...]
Researchers have created ‘nanomachines’ that use mechanical molecular motions to enter and destroy cells. Cancer is a condition where some of the body’s cells grow out of control and spread to other bodily regions. Cancer cells divide continually, leading them to invade surrounding tissue and form solid tumors. The majority of cancer treatments involve [...]
Explaining the behavior of trained neural networks remains a compelling puzzle, especially as these models grow in size and sophistication. Like other scientific challenges throughout history, reverse-engineering how artificial intelligence systems work requires a substantial amount of experimentation: making hypotheses, intervening on behavior, and even dissecting large networks to examine individual neurons. To date, [...]
In the past four years, the pathogen responsible for Coronavirus Disease 2019 (COVID-19), SARS-CoV-2, has infected more than 770 million people and caused more than 6.9 million deaths worldwide. The severe impact of SARS-CoV-2 is often attributed to its ability to suppress the interferon (IFN) response while simultaneously inducing the production of various cytokines. [...]
Researchers at the University of Bonn examine the inner workings of machine learning applications in drug research. Artificial intelligence (AI) has been advancing rapidly, but its inner workings often remain obscure, characterized by a “black box” nature where the process of reaching conclusions is not visible. However, a significant breakthrough has been made by [...]
New method developed by Johns Hopkins researchers could enhance the body's ability to fight cancer and make vaccines more effective in targeting tumors ByJohnny Moseman Johns Hopkins researchers have identified minuscule particles that supercharge therapeutic cancer vaccines, which train the immune system to attack tumors. These new lipid nanoparticles—tiny structures made of fat—not only [...]
Biomedical scientists from UC Riverside state that the cells resemble M cells found in the gut and airways. It came as a surprise to Professor David Lo and his graduate student Diana Del Castillo when they were recently consulted by researchers in Israel for their expertise on specialized cells called Microfold cells, or M cells, which are mostly [...]
A study led by Professor Sebyung Kang and Professor Sung Ho Park in the Department of Biological Sciences at UNIST has unveiled a remarkable breakthrough in cancer treatment. The research team has successfully developed unprecedented "NK cell-engaging nanodrones" capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable types of [...]
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular protein homologs. Typically, larger biologics that can target these proteins demand injection, limiting patient convenience and accessibility. In [...]
Functional ultrasound (fUS) marks a significant leap in Brain-Machine Interface technology, offering a less invasive method for precise control of electronic devices by interpreting brain activity. Brain–machine interfaces (BMIs) are devices that can read brain activity and translate that activity to control an electronic device like a prosthetic arm or computer cursor. They promise [...]
