Globally, cancer is the second leading cause of death, also because the efficiency of chemotherapeutics is inadequate due to poor delivery to the tumor. NIM scientist Prof Olivia Merkel and her team develop targeted nanocarrier systems to increase the delivery rates of therapeutic formulations and their specific uptake into the target cells.
In the treatment of cancer, there are still several limitations. Especially the delivery of sufficient amounts of active chemotherapeutic drug is difficult. After the conventional intravenous administration, the therapeutic formulation faces some hurdles before reaching the target site. In most cases, the blood circulation time of the active compound is rather short, and a substantial amount of the remaining active drug accumulates in non-target tissues and leads to the known unpleasant and unwanted side-effects in patients.
Therefore, the group of Professor Olivia Merkel focuses on the development of stable and targeted nanocarrier formulations and alternative administration routes. One approach is the targeting of specific sugar receptors expressed on several cancer cells, the mannose and mannose-6-phosphate receptors. The new publication in Advanced Healthcare Materials (“Mannose and Mannose-6-Phosphate Receptor–Targeted Drug Delivery Systems and Their Application in Cancer Therapy”) provides a nice overview of the field and presents first results of a new approach tested in the Merkel Lab.
Image Credit: C Hohmann
News This Week
A red-hot anti-aging strategy quietly passed its first test earlier this year after 14 volunteers took drugs meant to kill off old, toxic cells in their bodies. The small study in people with [...]
Since the discovery of biological ion channels and their role in physiology, scientists have attempted to create man-made structures that mimic their biological counterparts. New research by Lawrence Livermore National Laboratory (LLNL) scientists and [...]
Sometimes it is too cold for us and then too warm again - annoying dressing-undressing of sweaters and co. Is therefore required. However, that may change: researchers have developed a sophisticated textile that can [...]
What is Global Health Care Equivalency (GHCE)? Looking ahead over the next 10-30 years, with the rapid emergence of, and synergies between, the disciplines of nanotechnology, nanomedicine, and AI, we can envisage a future [...]
Researchers in Singapore have built a refrigerator that’s just three atoms big. This quantum fridge won’t keep your drinks cold, but it’s cool proof of physics operating at the smallest scales. The work is [...]
Note: This videoblog is in German. It was produced by the Institute of Art & Art Theory of the University of Cologne. Humanity faces epochal challenges in the age of digitization. In particular, [...]