Seeing RNA at the nanoscale (with video)

 

Cells contain thousands of messenger RNA molecules, which carry copies of DNA’s genetic instructions to the rest of the cell. MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map the location of RNA throughout cells.

Key to the new technique is expanding the tissue before imaging it. By making the sample physically larger, it can be imaged with very high resolution using ordinary microscopes commonly found in research labs.

“Now we can image RNA with great spatial precision, thanks to the expansion process, and we also can do it more easily in large intact tissues,” says Ed Boyden, an associate professor of biological engineering and brain and cognitive sciences at MIT, a member of MIT’s Media Lab and McGovern Institute for Brain Research, and the senior author of a paper describing the technique in the July 4, 2016 issue of Nature Methods (“Nanoscale imaging of RNA with expansion microscopy”).

 

Read more

 

 

Image credit: Yosuke Bando, Fei Chen, Dawen Cai, Ed Boyden, and Young Gyu

 

Recent News

Quantum dots in brain could treat Parkinson’s and Alzheimer’s diseases

Tiny particles called quantum dots reduce symptoms in mice primed to develop a type of Parkinson’s disease, and also block formation of the toxic protein clumps in Alzheimer’s. They could one day be a [...]

Three Huge Ways Tech Is Overhauling Healthcare

We are on the brink of a revolution in healthcare. AI is making the drug discovery process >100X faster and cheaper, and 90 percent more likely to succeed in clinical trials. Mobile health is [...]

Building a robotic eel that swims through your body

Physicist Seth Fraden is developing a new generation of machines modeled on living creatures. His latest invention might one day treat disease by swimming its way through our blood. As a kid, physicist Seth [...]

Richard Feynman “Tiny Machines” Nanotechnology Lecture Video

Richard Feynman gave his famous talk "There's Plenty of Room at the Bottom" (Original Transcript Available Here : http://muonray.blogspot.ie/2012/12/ri...) on December 29th 1959 at the annual meeting of the American Physical Society at [...]

Boosting immune cells with nanoparticles

Programming the body’s immune system to attack cancer cells has had promising results for treating blood cancers such as lymphoma and leukemia. This tactic has proven more challenging for solid tumors such as breast [...]

Analysis of Nanoparticles in Commercial Sunscreens

Postnova Analytics has published a new application note that describes a new approach for analysis of titanium dioxide nanoparticles in commercial sunscreens. The technique, which combines Inverse Supercritical Fluid Extraction (I-SFE) and Miniaturized Asymmetrical [...]

Future Space Tourists Might Have To Train Before Their Trips

Leave it to Richard Branson to find motivation to go to the gym in traveling to space. On Tuesday, a ship from Brason’s space flight company, Virgin Galactic, achieved supersonic speed in a test [...]

Artificial Intelligence to Boost Liquid Biopsies

Machine-learning algorithms tuned to detecting cancer DNA in the blood could pave the way for personalized cancer care. copyright by www.the-scientist.com Modern cancer medicine is hampered by two big challenges—detecting cancers when they are [...]

Engineer to combine math, machine learning and signal processing to lay groundwork for high-resolution microscope

Like our eyes, microscopes are limited in what they can see because of their resolution, or their ability to see detail. The detail, or information, from the object is there, but some of it [...]

Can blockchain be hacked? Spoiler alert… YES!

From an article by Dr. ir Johannes Drooghaag : Blockchain, by some seen as the answer to every problem, is promoted by many, including myself, as a possible solution for many cyber security issues. The [...]

AI that improves healthcare efficiency also threatens profits

Some medical technologies that use artificial intelligence might benefit patients but result in a drop in health system revenues. This could make widespread adoption of AI in medicine a tough sell. Healthcare is a [...]

The 9 Companies Behind the A.I. Acquisition Boom

Tech giants like IBM and Google have invested billions internally in A.I. research, but the past few years have also seen a wave of acquisitions, as big companies buy up startups to obtain top [...]

Diabetic Neuropathy Overview – What Is Diabetic Nerve Pain?

From endocrineweb.com: Diabetes can damage nerves throughout your body. In fact diabetic neuropathy (neuro- means nerves; -pathy means disease or suffering) is the most common, chronic complication of diabetes according to the American Diabetes [...]

Frank Boehm of NanoApps Medical and Chakravarthy Lab team

The primary goals of the Chakravarthy Lab are to investigate the pathophysiology and mechanisms of chronic pain in the context of complex regional pain syndrome (CRPS), diabetic neuropathy, persistent postsurgical pain and neuropathic pain.  Further, our lab [...]

Digital Globalization and Global Health Care Equivalency

The process of globalization is entering a new era characterized by soaring flows of cross-border information. As the locus shifts from physical networks of production and trade to global information networks. The global [...]

ING Bank Survey Reveals Interest in Crypto Will Double in Near Future

Research company Ipsos on behalf of ING Bank B.V. has conducted a study on how cryptocurrencies are perceived across Europe, Australia and the U.S., which reveals that interest in the technology is expected to [...]

Crowdfunding: a way for everyone to help change the future of medicine

From an article by Scott Wagers MD: A challenge that anyone working to bring new technology, therapies, or approaches from proof of concept to clinic implementation is funding. I have been tracking the concept [...]

Systems Thinking for Cybersecurity Education

From an article by Ludmila Morozova-Buss on LinkedIn: A word ‘unprecedented’ seems too weak to convey just how much the dimensionless operational space of digital (r)evolution requires instantaneous reaction. Striving for knowledge brought me far beyond my personal [...]

Google’s Masterplan for Healthcare

My Apple health chatbot referred me to the Amazon hospital where I got Google drugs... Verily, Calico, Deepmind - more than 150 patents in life sciences and countless collaborations with pharma companies. The search [...]

New Nanofabrication Technique Can Speed Up DNA Sequencing

The laborious, uneconomical process of sequencing DNA molecules - a technology used to identify, diagnose, and perhaps find treatments for diseases - could become much faster and cheaper thanks to a new nanofabrication technique [...]

Frank Boehm (NA CEO) signs with IOP for Book on Nanomedical Brain/Cloud Interface

NanoApps Medical Inc. CEO Frank Boehm has signed with IOP Publishing to produce Nanomedical Brain/Cloud Interface: Explorations and Implications - a book that will explore the notion of a nanomedically enabled Brain/Cloud Interface (B/CI). [...]

Who owns what in outer space?

In 2015 Congress passed a law to legalise mining in outer space—the first of its kind in the world. Firms that some day manage to mine asteroids for resources like water or precious metals [...]

Public, permissionless blockchains and the EU’s GDPR: The coming clash between technology and the law?

From a blog by VALID advisor Christian Sillaber, Senior Researcher on IT-Security The European Union’s General Data Protection Regulation (GDPR) came into effect on May 25, 2018. It is already clear that the new [...]

Women in Tech 2018: What the Statistics Tell Us

From an article by Ludmila Morozova-Buss on TechNative: Women have played a role in computer technology since its inception. Many credit Ava Lovelace as the first computer programmer, in a time before computers even existed, [...]

Minimalist biostructures designed to create nanomaterials

Researchers of the Institute of Biotechnology and Biomedicine (IBB-UAB) have generated four peptides, molecules smaller than proteins, capable of self-assembling in a controlled manner to form nanomaterials. The research, published in the journal ACS [...]

Nanophotonic System Translates Molecules into Bar Codes

EPFL scientists have developed a unique system that can be used for detecting and analyzing molecules with very a level of high precision and without using any bulky equipment. This latest development paves the [...]

Squeezing light at the nanoscale

Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a new technique to squeeze infrared light into ultra-confined spaces, generating an intense, nanoscale antenna that could be [...]

 

 

 

 

 

2018-03-22T14:37:02+00:00

Leave A Comment