Hydrogen bond base pairing forces are essential for the mechanisms associated with DNA stability. Despite attracting great research attention, this fundamental interaction has eluded a precise physical description so far since its electrical origin has not been quantified yet.
Researchers now have proposed characterization by means of electrical forces, providing a framework for universal characterization of hydrogen bonds. In this way, they provide technical arguments to support that hydrogen bonds are well distinguishable and their role in biological events require a proper specific intrabond description.
Published in PLOS One (“Unveiled electric profiles within hydrogen bonds suggest DNA base pairs with similar bond strengths”).
This is the first report on the electrical characterization of DNA with intrabond resolution.
Specifically, it quantifies electrical forces due to a single hydrogen bond in DNA and provides proof of a non-direct relationship between the number of hydrogen bonds in DNA pairs and the relative strengths of such pairs.
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