Circulating tumour cells (CTCs) are cancer cells that escape from primary tumour sites and enter the bloodstream. This metastasis is responsible for the majority of deaths from cancer. Monitoring the level of CTC levels in blood is thus important but has proved difficult to do. A team of researchers in China and the US has now developed a new way to isolate these cells using a technique called size-amplified acoustofluidics in which the CTCs selectively bind to microbeads.
The bound cancer cells are significantly different in terms of size and physical properties (they are stiffer, for example) compared to normal cells, explain the researchers led by Feng Guo of Indiana University in Bloomington in the US. This means that their acoustic radiation force is a 100-fold higher than that of bare CTCs or normal blood cells. They can thus be efficiently sorted from blood using microbeads (the “size-amplifiers”) in a travelling acoustic wave microfluidic device, and then released from the amplifiers by being degraded with enzymes.
The technique is 77% efficient and produces CTCs with a 96% yield.
Image Credit: Huiqin Liu
News This Week
A small clinical trial using gold nanoparticles that act as tumor-seeking missiles on a mission to remove prostate cancer has begun at The University of Texas Health Science Center at Houston (UTHealth). It [...]
A small clinical trial using gold nanoparticles that act as tumor-seeking missiles on a mission to remove prostate cancer has begun at The University of Texas Health Science Center at Houston (UTHealth). It is [...]
Nanomedical Device and Systems Design: Challenges, Possibilities, Visions now available to rent on Kindle
To accommodate students who wish to read the book at an affordable cost, Nanomedical Device and Systems Design: Challenges, Possibilities, Visions by Frank Boehm (CEO NanoApps Medical Inc.) is available to rent on Kindle. This book benefits [...]
Researchers at the Mount Sinai School of Medicine have developed a new nanotechnology-based immunotherapy that promotes long-term transplant acceptance in an animal model. The development, which is described in the journal Immunity, could transform [...]
“It’s a bit like driving past a vineyard and looking out the window at the vineyard rows. Every now and then, you see no rows because you’re looking directly along a row,” said Nathaniel [...]
The use of nanoparticles and other nanoscale materials has been gathering a lot of significant interest in recent years and has even adapted into its own interdisciplinary field of science known as nanomedicine. Whilst [...]